Ghrelin and SP1 with idiopathic fetal growth restriction of correlation
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摘要:
目的研究特发性胎儿生长受限新生儿脐血中生长激素释放多肽Ghrelin、妊娠特异性β1糖蛋白（SP1）的表达水平，探讨二者与特发性胎儿生长受限的关系。 方法选择不明原因胎儿生长受限新生儿30例为观察组，正常新生儿30例为对照组，用酶联免疫吸附测定法分别检测观察组和对照组新生儿脐血中Ghrelin和SP1的含量。 结果在观察组新生儿中，新生儿出生体质量与脐血Ghrelin水平（r=-0.215，P=0.041）呈负相关，与脐血SP1水平（r=0.376，P=0.035）呈正相关。在对照组新生儿中，新生儿出生体质量与脐血Ghrelin水平（r=-0.218，P=0.097），与SP1水平（r=-0.225，P=0.099）的关系均不明显。另外，观察组Ghrelin水平高于正常对照组，SP1水平低于正常对照组，差异有统计学意义。 结论高水平的Ghrelin，低水平的SP1可能是造成特发性胎儿宫内生长受限的原因。 Abstract:ObjectiveTo study the intrauterine growth retardation in fetal cord blood Ghrelin, SP1 expression levels, explore their relationships with intrauterine growth retardation. Methods30 cases of intrauterine fetal growth retardation, 30 cases of normal fetuses, using enzyme-linked immunosorbent assay were used to detect the normal newborn and intrauterine growth retardation and neonatal cord blood Ghrelin levels SP1. ResultsIn the observation group, newborns, birth weight and umbilical cord blood Ghrelin levels (r=-0.215, P=0.041) was negatively correlated with cord blood SP1 level (r=0.376, P=0.035) were positively correlated. Relations in the control group newborns, birth weight and umbilical cord blood Ghrelin levels (r=-0.218, P=0.097), with the SP1 level (r=-0.225, P=0.099) is not obvious. Observation group compared with the control group, Ghrelin levels higher than normal control group, SP1 level lower than the control group, the difference was statistically significant. ConclusionThe high levels of Ghrelin, low levels of SP1 might cause intrauterine growth retardation. -
Key words:
- Ghrelin /
- SP1 /
- intrauterine growth retardation
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表 1 观察组与对照组间Ghrelin、SP1水平的比较（n=30）
Ghrelin (ug/L) SP1 (mg/L) P 观察组 13.3±3.8 91.4±10.1 < 0.05 对照组 9.4±3.2 123.8±17.9 < 0.05 
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