Effect of valproate and oxcarbazepine on oxidative stress in benign childhood epilepsy with centrotemporal spikes children
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摘要:
目的 探讨丙戊酸和奥卡西平对儿童良性癫痫伴中央颞区棘波（BECT）患儿氧化应激水平的影响。 方法 选取正常儿童30例作为对照组，新诊断BECT患儿64例作为观察组，并通过随机数字法将64例患儿分成丙戊酸组和奥卡西平组，每组32例，两组患儿分别服用丙戊酸和奥卡西平治疗，分别在药物治疗前、治疗后3月、治疗后6月检测血浆一氧化氮、丙二醛及黄嘌呤氧化酶（XO）水平。 结果 观察组患儿血浆一氧化氮、丙二醛及XO水平高于对照组患儿（P<0.05）。丙戊酸组患儿治疗前、治疗后3月和6月血浆一氧化氮、丙二醛和XO水平差异无统计学意义（P>0.05）。奥卡西平组患儿治疗后3月和6月血浆一氧化氮、丙二醛和XO水平均显著低于治疗前（P<0.05）。 结论 BECT患儿体内氧化应激水平显著升高，丙戊酸对BECT患儿体内氧化应激水平无明显影响，奥卡西平可显著降低BECT患儿体内氧化应激水平，值得在临床上推广。 Abstract:Objective To explore the effect of valproate and oxcarbazepine on oxidative stress in benign childhood epilepsy with centrotemporal spikes (BECT) children. Methods Thirty healthy children were assigned to the control group, and 64 newly diagnosed BECT children were assigned to the experimental group. Moreover, 64 newly diagnosed BECT children in the experimental group were randomly assigned to the valproate (VPA) group (n=32) and the oxcarbazepine (OXC) group (n=32). Children in the VPA group and OXC group received VPA and OXC treatment, respectively. Nitric oxide (NO), malondialdehyde (MDA) and xanthine oxidase (XO) were detected before and 3 months and 6 months after treatment. Results NO, MDA and XO levels in the experimental group were significantly higher than that in the control group (P<0.05). There were no significant differences in NO, MDA and XO levels among before and 3 months and 6 months after VPA treatment (P>0.05). In the OXC group, NO, MDA and XO levels were significantly higher after 3 months and 6 months than that before treatment (P<0.05). Conclusion Oxidative stress is higher in BECT children. OXC could significantly reduce oxidative stress in BECT children while VPA could not, which is worth popularizing clinically. -
Key words:
- valproate /
- oxcarbazepine /
- benign childhood epilepsy /
- centrotemporal spikes /
- oxidative stress
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表 1 观察组与对照组患儿血浆一氧化氮、丙二醛和XO水平比较（Mean±SD）
组别 n NO（μmol/L） MDA（nmol/mL） XO（U/mL） 对照组 30 11.52±3.41 2.13±0.58 115.81±25.61 观察组 64 25.08±7.11* 2.48±0.62* 130.31±30.52* *P<0.05vs 对照组；MDA: 丙二醛；NO: 一氧化氮；XO: 黄嘌呤氧化酶. 
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表 2 丙戊酸组和OXC组患儿治疗前后血浆一氧化氮、丙二醛和XO水平比较（n=32, Mean±SD）
时间 丙戊酸组 OXC组 NO（μmol/L） MDA（nmol/mL） XO（U/mL） NO（μmol/L） MDA（nmol/mL） XO（U/mL） 治疗前 25.14±7.13 2.51±0.64 131.12±30.61 25.02±7.08 2.45±0.59 129.51±30.47 治疗后3月 24.57±6.92 2.46±0.57 129.47±31.17 21.13±5.15* 2.14±0.41* 113.42±23.62* 治疗后6月 24.42±6.88 2.39±0.53 128.73±30.82 19.49±4.93* 2.05±0.36* 108.85±21.17* *P<0.05vs 治疗前; MDA: 丙二醛；NO: 一氧化氮；XO: 黄嘌呤氧化酶；OXC: 奥卡西平.
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