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BRAF V600E突变与甲状腺乳头状癌的研究进展

朱国权 欧阳伟

朱国权, 欧阳伟. BRAF V600E突变与甲状腺乳头状癌的研究进展[J]. 分子影像学杂志, 2019, 42(1): 70-76. doi: 10.12122/j.issn.1674-4500.2019.01.17
引用本文: 朱国权, 欧阳伟. BRAF V600E突变与甲状腺乳头状癌的研究进展[J]. 分子影像学杂志, 2019, 42(1): 70-76. doi: 10.12122/j.issn.1674-4500.2019.01.17
Guoquan ZHU, Wei OUYANG. Progress of BRAF V600E mutation and papillary thyroid carcinoma[J]. Journal of Molecular Imaging, 2019, 42(1): 70-76. doi: 10.12122/j.issn.1674-4500.2019.01.17
Citation: Guoquan ZHU, Wei OUYANG. Progress of BRAF V600E mutation and papillary thyroid carcinoma[J]. Journal of Molecular Imaging, 2019, 42(1): 70-76. doi: 10.12122/j.issn.1674-4500.2019.01.17

BRAF V600E突变与甲状腺乳头状癌的研究进展

doi: 10.12122/j.issn.1674-4500.2019.01.17
基金项目: 广东建设高水平大学转化医学优势特色学科高层次人才培训示范项目(2016A070714008)
详细信息
    作者简介:

    朱国权,在读研究生,E-mail: 472235978@qq.com

    通讯作者:

    欧阳伟,博士研究生导师,主任医师,E-mail: oyw1963@sina.com

Progress of BRAF V600E mutation and papillary thyroid carcinoma

  • 摘要: 甲状腺乳头状癌(PTC)起源于甲状腺滤泡上皮细胞,预后一般较好。但近年来PTC的发病率急剧上升,严重影响公众健康,甲状腺乳头状癌常被分为几种亚型:经典型、滤泡亚型、高细胞亚型、平头钉亚型及弥漫硬化型等,不同亚型的侵袭性有所不同。BRAF V600E突变是甲状腺乳头状癌的最常见的分子标志物,也是近年来的分子研究热点,和PTC的发生发展机制、侵袭性及预后密切相关。随着BRAF V600E突变研究的不断深入,关于它与PTC之间关系的矛盾点及争论点慢慢浮现,本文就近5年来的相关文献进行综述,主要从BRAF V600E突变与PTC的作用发生机制、临床病理特征关系、预后、指导临床治疗及相关基因联合等方面进行阐述,并针对当前的争议点及矛盾点进行比较分析。

     

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  • 收稿日期:  2018-03-11
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