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抗缪勒氏管激素在多囊卵巢综合征诊断中的价值

熊紫薇 胡坚 陈薪宇 杨卫 刘刚

熊紫薇, 胡坚, 陈薪宇, 杨卫, 刘刚. 抗缪勒氏管激素在多囊卵巢综合征诊断中的价值[J]. 分子影像学杂志, 2015, 38(2): 80-83.
引用本文: 熊紫薇, 胡坚, 陈薪宇, 杨卫, 刘刚. 抗缪勒氏管激素在多囊卵巢综合征诊断中的价值[J]. 分子影像学杂志, 2015, 38(2): 80-83.
Ziwei Xiong, Jian Hu, Xinyu Chen, Wei Yang, Gang Liu. Clinical value of serum anti-mullerian hormone in diagnosis of polycystic ovarian syndrome[J]. Journal of Molecular Imaging, 2015, 38(2): 80-83.
Citation: Ziwei Xiong, Jian Hu, Xinyu Chen, Wei Yang, Gang Liu. Clinical value of serum anti-mullerian hormone in diagnosis of polycystic ovarian syndrome[J]. Journal of Molecular Imaging, 2015, 38(2): 80-83.

抗缪勒氏管激素在多囊卵巢综合征诊断中的价值

详细信息
    作者简介:

    熊紫薇,在读硕士研究生,主管检验师,E-mail: 40300646@qq.com

    通讯作者:

    刘刚,博士,副研究员,博士生导师,电话:0731-82355100-8901,E-mail: 616778747@qq.com

Clinical value of serum anti-mullerian hormone in diagnosis of polycystic ovarian syndrome

  • 摘要: 目的研究抗苗勒管激素(AMH)与多囊卵巢综合征(PCOS)激素特征的关系及使用ROC曲线法评价AMH对PCOS的诊断价值。方法576例PCOS患者血清AMH、卵泡刺激素(FSH)、黄体生成素(LH)、睾酮(T)、雌二醇(E2)水平用电化学发光法检测,并与503例月经周期正常妇女进行对照。用SPSS绘制ROC曲线及统计分析。结果(1)PCOS组血清激素(中位数)AMH 10.46 ng/ml、E2 40.92、LH 6.67、T 0.78水平,明显高于对照组AMH 3.65 ng/ml、E2 35.97、LH 6.45、T 0.48,且差异均具有统计学意义(P < 0.05);PCOS组FSH 5.14明显低于对照组(6.45),且差异具有统计学意义(P < 0.05);(2)Pearson相关分析显示PCOS组AMH与T、LH均呈正相关(相关系数分别为0.276,0.221,P < 0.05);与FSH呈负相关(r=-0.113,P < 0.05);与年龄、E2无明显相关;(3)以AMH诊断PCOS的ROC曲线下面积为0.926,面积的标准误为0.008,差异有显著意义(P=0.000);以AMH 6.99 ng/ml为PCOS诊断界值时,敏感性84%,特异性92%,诊断效能较高/价值明显高于E2、FSH、LH、T及年龄等其他指标。结论PCOS患者血清AMH显著升高,其升高可能与激素紊乱和卵泡发育异常有关。

     

  • 图  1  以AMH、E2、FSH、LH、T值及年龄诊断PCOS的ROC曲线

    表  1  PCOS组和对照组血清AMH及生殖激素水平结果比较

    组別对照组PCOS组
    例数576503
    年龄(岁)29.84±4.4227.93±3.75
    AMH (ng/ml)3.65±2.7110.46±3.89*
    E2(pg/ml)35.97±17.4940.92±50.58*
    FSH (mU/ml)6.45±2.055.14±1.27*
    LH (mU/ml)4.53±2.646.76±4.37*
    T (ng/ml)0.48±0.330.78±0.48*
    *:与对照组比较,P < 0.05.
    下载: 导出CSV

    表  2  PCOS组与对照组血清AMH和生殖激素水平及年龄之间的相关性

    组别 对照组PCOS组
    例数576503
    相关性rPrP
    年龄(岁)-0.3000.000-0.0510.257
    E2(pg/ml)-0.0530.2060.0430.339
    FSH (mU/ml)-0.1990.000-0.1130.011
    LH (mU/ml)0.3840.0000.2210.000
    T (mg/ml)0.0050.9060.2760.000
    下载: 导出CSV
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  • 收稿日期:  2014-10-21
  • 刊出日期:  2015-02-01

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