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乳腺癌微钙化形成的分子机制

张瑜 王文 米成嵘

张瑜, 王文, 米成嵘. 乳腺癌微钙化形成的分子机制[J]. 分子影像学杂志, 2018, 41(3): 306-310. doi: 10.3969/j.issn.1674-4500.2018.03.05
引用本文: 张瑜, 王文, 米成嵘. 乳腺癌微钙化形成的分子机制[J]. 分子影像学杂志, 2018, 41(3): 306-310. doi: 10.3969/j.issn.1674-4500.2018.03.05
Yu ZHANG, Wen WANG, Chengrong MI. Molecular mechanism of microcalcification in breast cancer[J]. Journal of Molecular Imaging, 2018, 41(3): 306-310. doi: 10.3969/j.issn.1674-4500.2018.03.05
Citation: Yu ZHANG, Wen WANG, Chengrong MI. Molecular mechanism of microcalcification in breast cancer[J]. Journal of Molecular Imaging, 2018, 41(3): 306-310. doi: 10.3969/j.issn.1674-4500.2018.03.05

乳腺癌微钙化形成的分子机制

doi: 10.3969/j.issn.1674-4500.2018.03.05
详细信息
    作者简介:

    张瑜:张 瑜,在读硕士研究生,E-mail: 45076457@qq.com

    通讯作者:

    米成嵘,主任医师,E-mail: mcr69333@163.com

Molecular mechanism of microcalcification in breast cancer

  • 摘要: 乳腺微钙化(MC)是乳腺癌重要的影像学特征。在乳腺组织中常见两种类型的MC物质,Ⅰ型MC(草酸钙)仅存在于良性病变中,而Ⅱ型MC(羟磷灰石)通常存在于恶性病变中。研究者们利用这一影像学特征制定和发明了先进的影像诊断程序和成像技术,然而MC形成的机制却了解甚少。因此,本文试图解释乳腺癌MC形成的分子机制,其重点在于部分异质性乳腺癌细胞如何获得成骨样表型并启动病理性钙化过程。同时,本文还强调了骨形成蛋白、肿瘤相关巨噬细胞以及上皮间质化过程在病理性钙化过程中的调控作用。

     

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出版历程
  • 收稿日期:  2018-04-28
  • 刊出日期:  2018-07-01

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