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动态18F-FDG PET/CT显像在恶性肿瘤中的研究进展

孔冉,  宾莉,  李玉娜,  翁娜,  王旭

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文章导航 > 分子影像学杂志  > 2021 >  44(5): 873-877
孔冉, 宾莉, 李玉娜, 翁娜, 王旭. 动态18F-FDG PET/CT显像在恶性肿瘤中的研究进展[J]. 分子影像学杂志, 2021, 44(5): 873-877. doi: 10.12122/j.issn.1674-4500.2021.05.28
引用本文: 孔冉, 宾莉, 李玉娜, 翁娜, 王旭. 动态18F-FDG PET/CT显像在恶性肿瘤中的研究进展[J]. 分子影像学杂志, 2021, 44(5): 873-877. doi: 10.12122/j.issn.1674-4500.2021.05.28
shu
KONG Ran, BIN Li, LI Yuna, WENG Na, WANG Xu. Research progress of dynamic 18F-FDG PET/CT imaging in malignant tumors[J]. Journal of Molecular Imaging, 2021, 44(5): 873-877. doi: 10.12122/j.issn.1674-4500.2021.05.28
Citation: KONG Ran, BIN Li, LI Yuna, WENG Na, WANG Xu. Research progress of dynamic 18F-FDG PET/CT imaging in malignant tumors[J]. Journal of Molecular Imaging, 2021, 44(5): 873-877. doi: 10.12122/j.issn.1674-4500.2021.05.28
shu

动态18F-FDG PET/CT显像在恶性肿瘤中的研究进展

doi: 10.12122/j.issn.1674-4500.2021.05.28
  • 1.

    滨州医学院附属医院核医学科，山东 滨州 256600

  • 2.

    滨州医学院，山东 滨州 256600

基金项目: 国家自然科学基金(81771828);山东省自然科学基金(ZR2017MH037);山东省高校计划(J18KB116)
详细信息
    作者简介:

    孔冉，硕士，住院医师，E-mail: 1622972022@qq.com

    通讯作者:

    王旭，硕士，副主任医师，E-mail: wangxu1978@163.com

Research progress of dynamic 18F-FDG PET/CT imaging in malignant tumors

  • 1.

    Department of Nuclear Medicine, Binzhou Medical University Hospital, Binzhou 256600, China

  • 2.

    Binzhou Medical University, Binzhou 256600, China

Funds: Supported by National Natural Science Foundation of China (81771828)

    摘要
  • 摘要: 18F-FDG PET/CT已广泛应用于恶性肿瘤的诊断、分期、疗效监测及预后评价。最大标准化摄取值是最常用的半定量评估指标，但它只是单点估计，忽略了18F-FDG摄取分布的变化，且易受多种因素影响。动态18F-FDG PET/CT检查是一个连续采集过程，可以利用动力学模型定量分析肿瘤组织对FDG的净摄取率，与传统的SUV相比，动态扫描可以对肿瘤微小代谢变化做出早期评估，更直接、有效地反映示踪剂的摄取。但因其扫描时间长、参数分析复杂等因素限制了临床应用，目前，随着多种简化扫描协议的开发，动态18F-FDG扫描已在多种恶性肿瘤中取得了初步研究成果。本文主要从动态18F-FDG PET/CT显像局限性及简化方案及动态18F-FDG PET/CT显像在肺癌、乳腺癌、胰腺癌、淋巴瘤、骨髓瘤、胶质母细胞瘤、软组织肉瘤恶性肿瘤中的应用中进行综述。

     

    Abstract: 18F- FDG PET/CT has been widely used in the diagnosis, staging, efficacy monitoring and prognosis evaluation of malignant tumors. SUVmax is the most commonly used semi-quantitative index, but it is only a single point estimation, ignoring the change of 18F- FDG uptake distribution, and it is susceptible to many factors. Dynamic 18F- FDG PET/CT is a continuous acquisition process that allows quantitative analysis of the net uptake rate of FDG in tumor by using a kinetic model. Compared with traditional SUVs, dynamic scanning can provide early assessment of small metabolic changes in tumors, reflecting tracer uptake more directly and effectively. However, due to its long scanning time and complicated parameter analysis, the clinical application is limited. Nowadays, with the development of a variety of simplified scanning protocols, dynamic 18F-FDG scanning has achieved preliminary research results in a variety of malignant tumors.

     

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