Clinical value of ultrasound-guided microwave ablation in the treatment of benign thyroid lesions
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摘要:
目的探讨超声引导下甲状腺微波消融治疗甲状腺良性病变的效果和安全性。 方法选取四川大学华西医院超声医学科2019年11月~2020年4月行超声引导下甲状腺微波消融治疗的甲状腺良性病变患者230例,治疗后1、3、6月复查超声,观察甲状腺结节的体积变化,检测甲状腺功能指标:游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH),检测甲状腺免疫抗体指标:抗甲状腺球蛋白抗体(TGAb)、抗甲状腺过氧化物酶抗体(TPOAb)、抗促甲状腺素受体抗体(TRAb),观察术后并发症。 结果与治疗前相比,甲状腺结节的体积在治疗后1、3、6月时逐渐缩小(P < 0.05);与治疗前相比,治疗后1、3、6月的血清FT3、FT4、TSH、TGAb、TPOAb、TRAb水平差异无统计学意义(P>0.05)。患者微波消融治疗后未发生喉返神经损伤、甲状旁腺损伤、甲状腺内出血、感染等严重并发症,颈部轻中度疼痛20例(8.70%),颈部肿胀26例(11.30%)。 结论超声引导下甲状腺微波消融治疗甲状腺良性病变具有良好的疗效和安全性,并发症少,对甲状腺功能基本无损害。 Abstract:ObjectiveTo explore the effect and safety of ultrasound- guided microwave ablation in the treatment of benign thyroid lesions. MethodsA total of 230 patients with benign thyroid lesions undergoing ultrasound-guided microwave ablation from November 2019 to April 2020 in department of ultrasound medicine, West China Hospital, Sichuan University were enrolled. Ultrasound re-examination was conducted at 1 month, 3 month and 6 months after treatment to observe the changes in volume of thyroid nodules. The thyroid function indexes [free triiodothyronine (FT3), free thyroxine (FT4), thyroidstimulating hormone (TSH)] and thyroid immune antibody indexes [anti-thyroglobulin antibody (TGAb), anti-thyroid peroxidase antibody (TPOAb), anti-thyrotropin receptor antibody (TRAb)] were detected. And postoperative complications were observed. ResultsCompared with those before treatment, the volume of thyroid nodules gradually decreased at 1 month, 3 months and 6 months after treatment (P < 0.05). Compared with those before treatment, there was no significant difference in levels of serum FT3, FT4, TSH, TGAb, TPOAb and TRAb at 1 month, 3 months and 6 months after treatment (P>0.05). After microwave ablation, there were no severe complications (recurrent laryngeal nerve injury, parathyroid injury, intrathyroid hemorrhage, infection). There were 20 cases (8.70%) with mild to moderate neck pain, and 26 cases (11.30%) with neck swelling. ConclusionThe effect and safety of ultrasound-guided microwave ablation are good in the treatment of benign thyroid lesions, with few complications and basically without damage to thyroid function. -
Key words:
- benign thyroid lesion /
- thyroid nodule /
- microwave ablation /
- ultrasound guidance /
- thyroid function
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图 1 女,26岁,甲状腺右侧叶良性滤泡性结节的超声影像图
A: 甲状腺右侧叶结节消融前二维图像, 超声显示甲状腺实质回声均匀, 右侧叶下方见大小约3.9 cm×1.4 cm×2.8 cm囊实混合回声团, 边界较清楚, 形态欠规则; B: 甲状腺右侧叶结节消融前彩色血流图像, 甲状腺结节内及周边可见点线状血流信号; C: 甲状腺右侧叶结节消融中图像; D: 甲状腺右侧叶结节消融术后图像, 可见汽化区覆盖至病灶边缘, 结节部分已消融.
Figure 1. The ultrasonic image of a 26-year-old female with benign follicular nodule in the right lobe thyroid
表 1 治疗前后甲状腺结节的体积变化
Table 1. The volume changes of thyroid nodules before and after treatment (Mean±SD)
时间 体积(cm3) 体积缩小率(%) 治疗前 4.21±1.05 - 治疗后1月 2.57±0.62* 38.95±9.22 治疗后3月 1.93±0.45* 54.16±13.05 治疗后6月 1.12±0.26* 73.40±18.11 χ2/F 373.486 153.616 P < 0.001 < 0.001 *P < 0.05 vs术前. 表 2 治疗前后甲状腺功能指标比较
Table 2. The comparison of thyroid function indexes before and after treatment (n=230, Mean±SD)
时间 FT3(pmol/L) FT4(pmol/L) TSH(mU/L) 治疗前 4.82±1.17 17.66±4.25 1.93±0.47 治疗后1月 4.96±1.12 18.13±4.18 1.86±0.42 治疗后3月 5.02±1.24 17.29±4.36 1.90±0.45 治疗后6月 4.93±1.09 17.55±4.30 1.96±0.49 F 1.208 1.553 1.999 P 0.306 0.199 0.113 FT3: 血清游离三碘甲腺原氨酸; FT4: 游离甲状腺素; TSH: 促甲状腺激素. 表 3 治疗前后甲状腺免疫抗体指标比较
Table 3. The comparison of thyroid immune antibody indexes before and after treatment (n=230, Mean±SD)
时间 TGAb(U/mL) TPOAb(U/mL) TRAb(U/L) 治疗前 59.31±14.72 20.18±4.93 0.80±0.18 治疗后1月 62.10±15.22 19.20±4.72 0.82±0.20 治疗后3月 60.38±14.09 19.63±5.01 0.83±0.22 治疗后6月 60.27±14.86 20.25±5.06 0.80±0.19 F 1.429 2.317 1.319 P 0.233 0.074 0.267 -
[1] Grani G, Sponziello M, Pecce V, et al. Contemporary thyroid nodule evaluation and management[J]. J Clin Endocrinol Metab, 2020, 105 (9): 2869-83. doi: 10.1210/clinem/dgaa322 [2] Wong R, Farrell SG, Grossmann M. Thyroid nodules: diagnosis and management[J]. Med JAust, 2018, 209(2): 92-8. [3] Erturk MS, Cekic B, Celik M. Microwave ablation of benign thyroid nodules: effects on systemic inflammatory response[J]. J Coll Physicians Surg Pak, 2020, 30(7): 694-700. doi: 10.29271/jcpsp.2020.07.694 [4] 郭艳, 夏雨, 戴理平, 等. 超声引导下甲状腺结节微波消融疗效分析[J]. 医学影像学杂志, 2020, 30(1): 138-40. https://www.cnki.com.cn/Article/CJFDTOTAL-XYXZ202001040.htm [5] 刘纯, 王敏, 陈良冬. 超声引导下微波消融与传统甲状腺手术治疗甲状腺良性肿瘤的疗效及对甲状腺功能的影响[J]. 解放军预防医学杂志, 2019, 37(9): 166-7. https://www.cnki.com.cn/Article/CJFDTOTAL-JYYX201909064.htm [6] 徐敬修, 王建国, 陈安, 等. 超声引导下微波消融与传统甲状腺手术治疗甲状腺良性肿瘤的疗效及对甲状腺功能的影响分析[J]. 山西医药杂志, 2021, 50(3): 397-400. doi: 10.3969/j.issn.0253-9926.2021.03.020 [7] 兰霞斌, 张浩. 《2015美国甲状腺学会成人甲状腺结节与分化型甲状腺癌诊治指南》外科治疗更新解读[J]. 浙江医学, 2016, 38(5): 313-6. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJYE201605003.htm [8] 王萍, 刘健, 岳文胜, 等. 2016版《甲状腺结节超声诊断指南》与《甲状腺影像报告及数据系统诊断标准》在甲状腺结节诊断中对比研究[J]. 实用医学影像杂志, 2018, 19(1): 10-3. https://www.cnki.com.cn/Article/CJFDTOTAL-SYXY201801004.htm [9] 武培梓, 马静. 左甲状腺素对良性甲状腺结节患者甲状腺功能及血脂的影响[J]. 中国实用医药, 2020, 15(33): 121-2. [10] Durante C, Grani G, Lamartina L, et al. The diagnosis and management of thyroid nodules: a review[J]. JAMA, 2018, 319(9): 914-24. doi: 10.1001/jama.2018.0898 [11] Khanh HQ, Hung NQ, Vinh VH, et al. Efficacy of microwave ablation in the treatment of large (≥3 cm) benign thyroid nodules[J]. World J Surg, 2020, 44(7): 2272-9. doi: 10.1007/s00268-020-05432-2 [12] 马树花. 超声引导下经皮微创消融治疗甲状腺结节的应用[J]. 分子影像学杂志, 2018, 41(3): 297-301. doi: 10.12122/j.issn.1674-4500.2018.03.03 [13] Mo HS, Wei L, Ye H, et al. Microwave ablation of visible benign thyroid nodules with different internal characteristics: a comparative study with follow-up results[J]. J Invest Surg, 2020: 1-7. doi: 10.1080/08941939.2020.1854903 [14] Shi YF, Zhou P, Zhao YF, et al. Microwave ablation compared with laser ablation for treating benign thyroid nodules in a propensityscore matching study[J]. Front Endocrinol (Lausanne), 2019, 10: 874. doi: 10.3389/fendo.2019.00874 [15] Zhi X, Zhao N, Liu YJ, et al. Microwave ablation compared to thyroidectomy to treat benign thyroid nodules[J]. Int J Hyperthermia, 2018, 34(5): 644-52. doi: 10.1080/02656736.2018.1456677 [16] Ni Y, Xu H, Ye X. Image-guided percutaneous microwave ablation of early-stage non-small cell lung cancer[J]. Asia Pac J Clin Oncol, 2020, 16(6): 320-5. doi: 10.1111/ajco.13419 [17] Sparchez Z, Mocan T, Radu P, et al. Microwave ablation in the treatment of liver tumors. A better tool or simply more power?[J]. Med Ultrason, 2020, 22(4): 451-60. doi: 10.11152/mu-2556 [18] Zhou WH, Herwald SE, McCarthy C, et al. Radiofrequency ablation, cryoablation, and microwave ablation for T1a renal cell carcinoma: a comparative evaluation of therapeutic and renal function outcomes [J]. J Vasc Interv Radiol, 2019, 30(7): 1035-42. doi: 10.1016/j.jvir.2018.12.013 [19] 于锋, 万文博. 超声引导下微波消融术对结节性甲状腺肿的疗效[J]. 中国现代普通外科进展, 2019, 22(5): 381-5. https://www.cnki.com.cn/Article/CJFDTOTAL-PWJZ201905012.htm [20] Yan J, Qiu TH, Lu J, et al. Microwave ablation induces a lower systemic stress response in patients than open surgery for treatment of benign thyroid nodules[J]. Int J Hyperthermia, 2018, 34(5): 606- 10. doi: 10.1080/02656736.2018.1427286 [21] 姜玉石, 王皓, 陈伟, 等. 液体隔离技术在甲状腺微波消融的应用[J]. 四川医学, 2020, 41(7): 752-5. https://www.cnki.com.cn/Article/CJFDTOTAL-SCYX202007020.htm [22] 闫磊, 章建全, 曹昆昆, 等. 微波消融改善甲状腺结节粗针穿刺活检的过程与结果[J]. 第二军医大学学报, 2017, 38(10): 1250-5. https://www.cnki.com.cn/Article/CJFDTOTAL-DEJD201710006.htm