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光动力疗法在头颈部恶性肿瘤中的应用

李艳阳 何华蓉 张梦蓝 李黎波

李艳阳, 何华蓉, 张梦蓝, 李黎波. 光动力疗法在头颈部恶性肿瘤中的应用[J]. 分子影像学杂志, 2020, 43(2): 213-216. doi: 10.12122/j.issn.1674-4500.2020.02.07
引用本文: 李艳阳, 何华蓉, 张梦蓝, 李黎波. 光动力疗法在头颈部恶性肿瘤中的应用[J]. 分子影像学杂志, 2020, 43(2): 213-216. doi: 10.12122/j.issn.1674-4500.2020.02.07
Yanyang LI, Huarong HE, Menglan ZHANG, Libo LI. Application of photodynamic therapy in malignant tumors of head and neck[J]. Journal of Molecular Imaging, 2020, 43(2): 213-216. doi: 10.12122/j.issn.1674-4500.2020.02.07
Citation: Yanyang LI, Huarong HE, Menglan ZHANG, Libo LI. Application of photodynamic therapy in malignant tumors of head and neck[J]. Journal of Molecular Imaging, 2020, 43(2): 213-216. doi: 10.12122/j.issn.1674-4500.2020.02.07

光动力疗法在头颈部恶性肿瘤中的应用

doi: 10.12122/j.issn.1674-4500.2020.02.07
基金项目: 

广东省自然科学基金 2016A030313526

详细信息
    作者简介:

    李艳阳,硕士,E-mail: 1099128764@qq.com

    通讯作者:

    李黎波,博士,主任医师,硕士生导师,E-mail: libo@fimmu.com

Application of photodynamic therapy in malignant tumors of head and neck

  • 摘要: 光动力治疗是近些年不断兴起的肿瘤治疗手段,将光敏剂注射到体内后,光敏剂能特异性聚集在肿瘤组织中,再予以特定波长的光照射肿瘤部位,使光敏剂产生光动力学反应,使肿瘤细胞器损伤、肿瘤细胞凋亡及坏死、肿瘤微循环障碍、机体肿瘤免疫等作用机制杀死肿瘤细胞。近年来,作为光动力疗法的关键因素,新的光敏剂及光源不断被探索并应用于临床,关于光动力治疗恶性肿瘤的临床研究日益增多,尤其是头颈部恶性肿瘤。随着新型光敏剂如金丝桃素及相关光源投入使用以及将光动力技术与其他治疗手段相结合后,光动力治疗效果主要观察指标“生存时间”较既往有所延长,相关不良反应如日光性皮炎、药物过敏反应等有所减少,且其在保存重要器官功能完整和美容功能上令人满意。本文对近年来光动力治疗在头颈部恶性肿瘤的临床应用做一综述,重点阐述光动力治疗鼻咽癌、鼻窦癌、喉癌、口腔癌、面部皮肤恶性肿瘤等头颈部常见恶性肿瘤时所体现的疗效好、完整保存重要器官功能、美容及副作用小的优越性,以了解近些年光动力技术对头颈部恶性肿瘤疗效的发展,及表达需进一步研发性能更优的光敏剂和光源、寻找光动力疗法结合其他治疗手段的需求。

     

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  • 收稿日期:  2020-02-06
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