Biological characteristics of FOXK1 and its research progress in various tumors
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摘要: 叉头框K1（FOXK1）是近年来广受研究关注的FOX转录因子家族成员之一。越来越多的研究表明，FOXK1与生殖、神经和消化等多种系统的肿瘤密切相关，FOXK1可通过调节细胞周期、细胞自噬以及介导信号转导通路，参与各个系统肿瘤的发生发展，影响肿瘤侵袭、转移及患者的预后。FOXK1在各个系统肿瘤组织中的特异性表达及其作用机制的研究，为肿瘤的诊治提供了新方向。本文就FOXK1的基因特征、生物学功能及其与各系统肿瘤的关系进行综述并作展望。
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关键词:
- FOXK1基因 /
- Wnt/β-catenin信号通路 /
- 肿瘤
Abstract: Fork head box 1 (FOXK1) is one of the members of the FOX transcription factors family that has attracted increasing attention in recent years. More and more studies have shown that FOXK1 is closely related to various tumors such as cancer of reproductive, nervous and digestive systems. Through regulating cell cycle, autophagy and mediating signal pathway, FOXK1 influences tumor invasion and metastasis. It affecting the prognosis of patients. The research of expression of FOXK1 in various tumor tissues and its mechanism provide a new direction for the diagnosis and treatment of tumors.-
Key words:
- FOXK1 gene /
- Wnt/β-catenin signaling pathway /
- neoplasms
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表 1 FOXK1在各种肿瘤中的表达及可能机制
肿瘤类型 FOXK1表达水平 可能的调节机制 参考文献 食管癌 上调 尚未阐明 [25] 卵巢癌 上调 抑制p21转录促进细胞增殖 [16] 弥漫大B细胞淋巴瘤 上调 靶向miR-17 [18] 乳腺癌 下调 抑制Twist和VEGF转录 [24] 前列腺癌 上调 正向调控Wnt/β-catenin通路 [19] 神经胶质瘤 上调 激活Wnt/β-catenin通路 [20] 下调 ZRANB2-SNHG20-FOXK1通路 [21] 胶质母细胞瘤 上调 激活Snail转录促进EMT [23] 肺癌 上调 circMAN2B2/miR-1275/FOXK1通路 [17] 肝细胞性肝癌 上调 TGF-β- FOXK1 - Wnt信号通路 [26] 通过Akt/mTOR通路抑制糖酵解 [27] 胃癌 上调 c-jun-FOXK1通路 [28] miR-646通过下调FOXK1抑制Bcl-2/Akt通路 [24] LINC02163-miR-593-3p/FOXK1通路 [29] 与波形蛋白相互作用促进EMT [30] 结直肠癌 上调 FOXK1- RUFY3通路 [35, 36] 与FHL2共表达诱导EMT [33] FOXK1-Cyr61-Snail通路 [37] LINC01503/miR-4492/FOXK1通路 [38] 
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