Research progress on drug loading for dental implant
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摘要: 种植已成为修复牙列缺损和缺牙的重要方法,而种植体周围炎是导致种植体失败的重要原因。为提高种植体的成功率,寻找有效的预防种植体周围炎症的方法是非常重要的。本文就种植体表面改性、载药载体两方面的研究状况及进展进行综述,结果表明表面改性对宿主的副作用不大,但其抗菌活性相对较弱;以二氧化钛纳米管、磷酸钙等为载体的复合抗菌涂料具有良好的抗菌性能,但仍存在药物释放率和释放量难以控制、难以维持长期抗菌活性等问题,有待进一步研究和解决。Abstract: Implantation has become an important method to repair dentition defect and missing teeth, and peri-implant inflammation is an important cause of implant failure. In order to improve the success rate of implants, it is very important to find effective methods to prevent inflammation around implants. This article reviews the research status and progress of implant surface modification and drug carrier. The results show that surface modification has little side effect on the host, but its antibacterial activity is relatively weak. The composite antibacterial coating with titanium dioxide nanotubes, calcium phosphate and other carriers has good antibacterial properties.But there are still some problems such as drug release rate and release amount difficult to control, difficult to maintain long-term antibacterial activity and so on, which need further research and solution.
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