Progress of histone deacetylase in regulating osteogenesis/odontogenic differentiation
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摘要: 基于非基因序列改变所致基因表达水平变化,如DNA甲基化和染色质构象变化等被称为表观遗传学。近年来,大量学者致力于研究表观遗传学对于多种组织中成体干细胞多向分化能力的影响,包括DNA甲基化修饰、组蛋白共价修饰、染色质重塑、基因沉默和RNA编辑等调控机制。口腔来源的成体干细胞是一类易于获得的人成体干细胞,这类细胞在组织工程学,特别是骨、牙齿再生的过程中是重要的种子细胞。研究表明,成体干细胞成骨/成牙本质向分化过程受组蛋白去乙酰化酶调控。同时,牙齿再生对于临床治疗有巨大的影响。本文阐述了组蛋白去乙酰化酶调节成骨/成牙本质向分化的研究进展以及其在牙再生医学中的应用前景。
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关键词:
- 组蛋白去乙酰化酶家族 /
- 口腔来源成体干细胞 /
- 成骨/成牙本质向分化
Abstract: Epigenetics is called epigenetics because of changes in gene expression level caused by non-gene sequence changes, such as DNA methylation and chromatin conformation changes. In recent years, a large number of scholars have focused on the effects of epigenetics on the multidirectional differentiation of adult stem cells in various tissues, including DNA methylation modification, histone covalent modification, chromatin remodeling, gene silencing and RNA editing. Oral-derived adult stem cells are a kind of human adult stem cells which are easy to obtain. These cells are important seed cells in tissue engineering, especially in the process of bone and tooth regeneration. Studies have shown that the osteogenic/odontogenic differentiation of adult stem cells is regulated by histone deacetylase. At the same time, tooth regeneration has a tremendous impact on clinical treatment. This paper reviews the progress of histone deacetylase in regulating osteogenesis/odontogenic differentiation and its application in dental regeneration medicine. -
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