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细胞自噬在神经病理性疼痛中的分子机制

王文淼 姜玖良 马宁 孙颖 董楷 徐悦 谭文彬 刘宏生

王文淼, 姜玖良, 马宁, 孙颖, 董楷, 徐悦, 谭文彬, 刘宏生. 细胞自噬在神经病理性疼痛中的分子机制[J]. 分子影像学杂志, 2019, 42(2): 222-226. doi: 10.12122/j.issn.1674-4500.2019.02.19
引用本文: 王文淼, 姜玖良, 马宁, 孙颖, 董楷, 徐悦, 谭文彬, 刘宏生. 细胞自噬在神经病理性疼痛中的分子机制[J]. 分子影像学杂志, 2019, 42(2): 222-226. doi: 10.12122/j.issn.1674-4500.2019.02.19
Wenmiao WANG, Jiuliang JIANG, Ning MA, Ying SUN, Kai DONG, Yue XU, Wenbin TAN, Hongsheng LIU. Molecular mechanism of autophagy in neuropathic pain[J]. Journal of Molecular Imaging, 2019, 42(2): 222-226. doi: 10.12122/j.issn.1674-4500.2019.02.19
Citation: Wenmiao WANG, Jiuliang JIANG, Ning MA, Ying SUN, Kai DONG, Yue XU, Wenbin TAN, Hongsheng LIU. Molecular mechanism of autophagy in neuropathic pain[J]. Journal of Molecular Imaging, 2019, 42(2): 222-226. doi: 10.12122/j.issn.1674-4500.2019.02.19

细胞自噬在神经病理性疼痛中的分子机制

doi: 10.12122/j.issn.1674-4500.2019.02.19
基金项目: 济宁市科技助推新旧动能转换计划项目(2017SMNS001);济宁医学院科研扶持基金(JY2017KJ045);济宁医学院大学生创新训练计划项目(cx2018012);济宁市重点研发计划(2017ZDGH031)
详细信息
    作者简介:

    王文淼,本科,E-mail:875531020@qq.com

    通讯作者:

    谭文彬,教授,硕士生导师,E-mail:1392144@163.com

    刘宏生,主任医师,硕士生导师,E-mail:18678766889@163.com

Molecular mechanism of autophagy in neuropathic pain

  • 摘要: 神经病理性疼痛是由躯体感觉神经系统的损伤或疾病而直接造成的疼痛,涉及多种细胞、分子和通路。自噬参与神经病理性疼痛的生理病理过程,可能与炎症因子,氧化应激等机制有关。研究发现,mTOR、TLR、P62、Wnt、JNK、HIF等均参与神经病理性疼痛的自噬过程。在表观遗传学上,miRNA-195的可使外周神经损伤所致的自噬受到抑制,进而加剧神经病理性疼痛。神经病理性疼痛与自噬有关的各条通路又错综复杂,对神经病理性疼痛关于自噬的药物研发或治疗试验面临挑战。本文对细胞自噬与神经病理性疼痛的研究进展作一综述。

     

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  • 收稿日期:  2019-01-19
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