Research progress of gastric cancer related LncRNA Gas5/miRNA signaling pathway
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摘要: 胃癌是消化系统中好发的恶性肿瘤之一。近年来,随着临床诊疗技术的提高,胃癌的5年生存率有了显著上升趋势,而进展期胃癌预后仍不理想。明确胃癌发病的分子机制与寻找新的分子靶点成为胃癌治疗中的关键。本文归纳了近年来国内外学者对长链非编码RNA Gas5在胃癌患者中通过调控相关miRNA表达影响胃癌发生发展的研究,指出LncRNA Gas5在胃癌中的表达机制,及其对相关miRNA影响的主要研究进展,并就该分子机制在胃癌生长、增殖、转移、预后等过程中起到的临床诊疗意义进行探讨。
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关键词:
- 长链非编码RNA /
- LncRNA Gas5 /
- miRNA /
- 胃癌
Abstract: Gastric cancer(GC) is one of the most common malignant tumors in the digestive system. In recent years, with the improvement of clinical diagnosis and treatment, the 5-year survival rate of gastric cancer has a significant upward trend, but the prognosis of advanced gastric cancer is still not ideal. Therefore, understanding the molecular mechanism of gastric cancer and finding new molecular targets becomes the key to the treatment of gastric cancer. In this paper, the recent studies on the effect of long noncoding RNA Gas5 on the carcinogenesis and development of gastric cancer by regulating the expression of miRNA in patients with gastric cancer were summarized. The expression of LncRNA Gas5 in gastric cancer and the main research progress of its effect on miRNA were pointed out. The clinical significance of this process in the growth, proliferation, metastasis and prognosis of gastric cancer was discussed.-
Key words:
- long noncoding RNA /
- LncRNA Gas5 /
- miRNA /
- gastric cancer
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