光声成像技术在早期肝癌诊断和治疗中的应用

石磊; 田昊; 张希恬; 龙子宁; 黄畅; 曾宁; 方驰华

doi:10.12122/j.issn.1674-4500.2019.02.01

光声成像技术在早期肝癌诊断和治疗中的应用

doi: 10.12122/j.issn.1674-4500.2019.02.01

石磊^1,,
田昊¹,
张希恬¹,
龙子宁¹,
黄畅¹,
曾宁^2, ,,
方驰华²

1.
南方医科大学第二临床医学院
2.
广东省数字医学临床工程技术研究中心，广东广州 510282

基金项目: “十二五”国家高技术研究发展（863）计划（2012AA021105）；“十三五”国家重点研发计划数字诊疗装备研发重点专项（2016YFC0106500）；NSFC-广东联合基金项目（U1401254）；国家自然科学基金重大仪器项目（81627805）；广州市科技计划（201604020144）

详细信息

作者简介:
石磊：石磊，本科，E-mail: 1159288437@qq.com

通讯作者:
曾宁，博士，副主任医师，E-mail: chen_ning16@foxmail.com

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- 被引次数: 0
出版历程
- 收稿日期: 2019-01-15
- 刊出日期: 2019-04-01

Application of PAI in the diagnosis and treatment of early liver cancer

1.
The Second Clinical Medical College, Southern Medical University
2.
Digital-medicine Clinical Engineering Technology Research Center of Guangdong, Guangzhou 510282, China

摘要

摘要: 光声成像技术具有光学成像高分辨率和超声成像高穿透深度的优点，能同时获取生物组织结构信息与分子、细胞和血氧饱和度等功能信息，可提供活体深层组织高分辨率的医学影像。近年来，光声成像技术在肝脏恶性肿瘤诊断与治疗中的应用逐渐受到重视，新的成像系统陆续出现，各种纳米探针在手术导航的精确度越来越高，随着技术的进步，更多边界界定及探针技术将会涌现。本文将对光声成像原理、光声成像系统进行介绍，并概括光声成像系统在肝癌临床治疗过程中的广泛应用，有助于临床对肝脏肿瘤的早期诊断和精准治疗。
- 光声成像 /
- 图像重建 /
- 早期肝癌 /
- 边界确定
Abstract: Photoacoustic imaging (PAI) is a kind of nondestructive biomedical imaging technology. It provides deeper tissue imaging with high spatial resolution along with functional imaging. Recently, PAI technology has developed significantly in early diagnosis and accurate boundary recognition of liver cancer. The new imaging system are emerging, and various nano-probes are more accurate in surgical navigation. As PAI technology advances, more boundary demarcation and probe techniques will come to the fore. The principle and imaging system of photoacoustic are introduced in this paper. The wide application of PAI system in clinical treatment of liver cancer is summarized, which are beneficial for early diagnosis and accurate treatment of liver cancer.
- photoacoustic imaging /
- image reconstruction /
- early liver cancer /
- boundary defining

HTML全文

图 1 光学分辨率光声显微镜成像系统图

下载: 全尺寸图片幻灯片

图 2 声学分辨光声显微成像系统

A: AR-PAM模式图; B: 系统实物图

下载: 全尺寸图片幻灯片

图 3 OR-PAM与AR-PAM成像对比

二者皆为小鼠耳尖血管网的成像图, A: AR-PAM成像; B: OR-PAM成像.

下载: 全尺寸图片幻灯片

图 4 PAT对纳米金笼造影剂靶向富集监测

红色为血管，金色为被靶向的肿瘤

下载: 全尺寸图片幻灯片

图 5 IVPAI成像效果图

下载: 全尺寸图片幻灯片

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