氧化应激与自噬在动脉粥样硬化发生发展中的研究进展

薛万华; 杨婷

doi:10.12122/j.issn.1674-4500.2019.01.22

氧化应激与自噬在动脉粥样硬化发生发展中的研究进展

doi: 10.12122/j.issn.1674-4500.2019.01.22

薛万华,
杨婷^,

德州市人民医院检验科，山东德州 253000

详细信息

作者简介:
薛万华：薜万华，主任技师，E-mail: 543328707@qq.com

通讯作者:
杨婷，硕士，检验技师，E-mail: yangting8912@126.com

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- 被引次数: 0
出版历程
- 收稿日期: 2018-08-13
- 刊出日期: 2019-01-01

Recent advances in atherosclerosis of oxidative stress and autophagy

Wanhua XUE,
Ting YANG^,

Department of Clinical Laboratory, Dezhou People’s Hospital, Dezhou 25300, China

摘要

摘要: 动脉粥样硬化是一种以大中动脉血管壁脂质堆积和慢性炎症反应为特点的疾病，其发生过程十分复杂，目前对其发生发展机制的研究已形成多种学说，氧化应激学说是其重要组成部分，当机体产生的高活性氧自由基在粥样硬化斑块处堆积时，会造成血管损伤，促进动脉粥样硬化的发生。自噬是细胞清除胞内错误折叠的蛋白质或受损细胞器，维持内环境稳态的重要方式，研究证明其在动脉粥样硬化过程中也起着重要作用。本文主要对近年来氧化应激和自噬在动脉粥样硬化发生发展中的研究新进展做一综述，为进一步阐明动脉粥样硬化的发生机制和未来进行针对性治疗提供理论基础。
- 氧化应激 /
- 自噬 /
- 动脉粥样硬化
Abstract: Atherosclerosis is a characterized by the accumulation of lipids and chronic inflammation in the large and middle-sized vascular arterial wall. The cause of Atherosclerosis and occurrence mechanism is not understood clearly. Oxidative stress is considered to be integral to the development and progression of atherosclerosis. The overproduction of reactive oxyen species (ROS) will damage the artery and promote atherosclerosis. Autophagy plays a crucial role in cell homeostasis by eradicating misfolded proteins and damaged cell organelles. Emerging evidence suggests that autophagy may be very importan in the pathogenesis of atherosclerosis. This review focus on the recent advaces of oxidative stress and autophagy in atherosclerosis, in order to further clarify the mechanism and provide the theoretical basis for targeted treatments.
- oxidative stress /
- autophagy /
- atherosclerosis

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参考文献(30)

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